Evaluation of Effectiveness of Bioactive Principles of Mucuna pruriens Seeds

Mucuna pruriens Linn. (DC) seeds are natural popular remedy, clinically used for the management of Parkinson’s disease. Depression is most common non-motor symptom associated with Parkinsonism.

Present study evaluates effect of bioactive constituents of the M. pruriens seeds in experimental models of depression associated with Parkinsonism.

Methods and Findings: Effect of 14 days treatment of isolated levodopa (ILD), alkaloid fraction (AF) and amino acid fraction (AAF) of the M.

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Pioglitazone Hydrochloride/SDS Modified Carbon Paste Electrode for Electrochemical Determination of Dopamine: A Cyclic Voltammetric Study

The drug based sensor was fabricated for the electrochemical determination of dopamine, carbon paste electrode was modified using Pioglitazone Hydrochloride drug and anionic surfactant sodium dodecyl sulphate.

The electrochemical parameters of the fabricated electrode were scrutinized by cyclic voltammetry and differential pulse voltammetric techniques. The modified Pioglitazone Hydrochloride/SDS carbon paste electrode had excellent electro catalytic property with promising selectivity towards the detection of dopamine in presence uric acid and ascorbic acid.

The detection limit of dopamine and uric acid were found to be 1.081 nd 1.147 μM respectively. The proposed sensor was successfully fit for the analysis of dopamine in pharmaceutical sample.

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Solvent Substitution Evaluation of Limestone Water as a Medium for Benzoylation

“No coopora nisi fluida”, the terms depicts extent and need of solvent for a chemical reaction to proceed, was coined by Greece Philosopher Aristotle.

However, it has now been found that reactions to an extent may occur even in solventless environment where host reactant and attacking reagent directly comes in contact with each other.

Both the techniques when compared in terms of synthetic scenario have their own pros and cons nevertheless use of solvent to assist a chemical reaction is still unquestionable owing to their decisive direct influence on outcomes such as reaction rate, product purity, its yield, economic value, and eco-friendly technique.

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Cyclosporine/SDS Modified Carbon Paste Electrode for Electrochemical Study of Dopamine

A sensitive electrochemical sensor was developed by cyclosporine and sodium dodecyl sulphate for the electrochemical detection of dopamine (DA).

The modified Cyclosporine carbon paste electrode was further modified by immobilization of sodium dodecyl sulphate (SDS) as a surfactant.

The Modified Cyclosporine/SDS carbon paste electrode showed an excellent electro catalytic activity towards the oxidation of dopamine.

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