Crossed Aldol Condensation (CAC) as a Feasible Route for Synthesis of a 1, 2-Unsaturated Carbonyl Compound-1,3 Diphenylpropenone

Acrolein, acrylic acid, crotonaldehyde, crotonic acid, ethyl crotonate, isocrotonic acid, fumeric acid, maleic acid, maleic anhydride, methyl acrylate are few examples of compounds bearing 1,2-unsaturated carbonyl functionality, characterized by presence of keto-ethylenic moiety separated by a single C-C bond.

This unique configuration assigns the molecule an reactive double bond amenable to get attack by nucleophile at 1st as well 2nd position however 2nd predominate leading to formation of 1,4 addition type product. Synthetically, the 1,2-unsaturated carbonyl compounds can be synthesize by numerous synthetic pathways, aldol reaction among meritoriously distinguished.

Aldol condensation represents an important class of selfcondensing reactions providing unique synthetic platform for yielding 1,2-unsaturated carbonyl compounds, further chemically modified as per applicability. 

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