Crossed Aldol Condensation (CAC) as a Feasible Route for Synthesis of a 1, 2-Unsaturated Carbonyl Compound-1,3 Diphenylpropenone

We here report an optimized crossed aldol method for synthesis of 1,2-unsaturated carbonyl compound, 1,3-diphenylpropenone (82-93% yield) rely on alcoholic base assisted condensation of arylmethyl ketone with aromatic aldehydes.

The method simply follows the conventional synthetic route however an extraordinary control over various reaction parameters enhance its synthetic practicability. Furthermore, a comparative study has been done to explore the scope for synthesis of 1,3-diphenylpropenone by crossed aldol reaction by solvent assisted method (SAM) and solvent-less method (SLM).

Undeniably, solvent-less technique (90-95% yield) hold superiority however tuning of certain reaction parameters, leveled-up solvent assisted crossed aldol reaction, but not to an analogues platform.

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Phytochemical Evaluation of Various Solvent Extracts of the Leaves, Fruits and Shoots of Ferula Jaeschkeana Vatke

The genus Ferula possess strong aromatic smell due to the presence of essential oil or oleoresin and is well-known in folk medicine for the treatment of various disorders. The present study aimed to investigate the presence of phytochemicals in various solvent extracts of leaves, fruits and shoots of Ferula jaeschkeana Vatke.

This study investigates the effects of ethanol, methanol, chloroform, petroleum ether and aqueous extracts of leaves, fruits and shoots. Phytochemical screening revealed the presence of various phytochemical constituents in the extracts of leaves, fruits and shoots.

Phytochemical analysis of extracts of leaves confirmed the presence of flavonoids, alkaloids, terpenoids, saponins, phenolic compounds, proteins, anthraquinone glycosides, phytosterols, tannins, steroids, coumarins, quinones, carbohydrates, resins, triterpenoids and xanthoproteins, while it gave the negative results for cardiac glycosides, amino acids, phlobotannins and oxalates.

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Advances in Triterpenoid Saponins Research 2007-2012

Triterpenoid saponins isolated and identified from natural resources during the period April, 2007-December, 2012 are reviewed. Current techniques used in their isolation and structure determination are discussed.

New triterpenoid saponins isolated along with their occurrence, selected physical data, spectroscopic methods used for their identification and the 13C NMR data of the novel aglycones of the parent saponins are compiled.

The biological properties of those molecules are also included. Green corrosion inhibition effects of saponins and biosynthesis of triterpenoid saponins and production of triterpenoid saponins by tissue culture of those molecules are also discussed.

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Evaluation of Effectiveness of Bioactive Principles of Mucuna pruriens Seeds Using Experimental Models of Depression Associated with Parkinsonism and Associated Neurotransmitter Turnover

Mucuna pruriens Linn. (DC) seeds are natural popular remedy, clinically used for the management of Parkinson’s disease. Depression is most common non-motor symptom associated with Parkinsonism.

Present study evaluates effect of bioactive constituents of the M. pruriens seeds in experimental models of depression associated with Parkinsonism.

Effect of 14 days treatment of isolated levodopa (ILD), alkaloid fraction (AF) and amino acid fraction (AAF) of the M. pruriens seeds were investigated in the catalepsy test, forced swim test, rotarod test and locomotor activity test after haloperidol challenge in mice.

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