We here report an
optimized crossed aldol method for synthesis of 1,2-unsaturated carbonyl
compound, 1,3-diphenylpropenone (82-93% yield) rely on alcoholic base assisted
condensation of arylmethyl ketone with aromatic aldehydes.
The method
simply follows the conventional synthetic route however an extraordinary
control over various reaction parameters enhance its synthetic practicability.
Furthermore, a comparative study has been done to explore the scope for
synthesis of 1,3-diphenylpropenone by crossed aldol reaction by solvent
assisted method (SAM) and solvent-less method (SLM).
Undeniably,
solvent-less technique (90-95% yield) hold superiority however tuning of
certain reaction parameters, leveled-up solvent assisted crossed aldol
reaction, but not to an analogues platform.
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