Mucuna pruriens
Linn. (DC) seeds are natural popular remedy, clinically used for the management
of Parkinson’s disease. Depression is most
common non-motor symptom associated with Parkinsonism.
Present study
evaluates effect of bioactive constituents of the M. pruriens seeds in
experimental models of depression associated with Parkinsonism.
Effect of 14 days
treatment of isolated levodopa (ILD), alkaloid fraction (AF) and amino acid
fraction (AAF) of the M. pruriens seeds were investigated in the catalepsy
test, forced swim test, rotarod test and locomotor activity test after
haloperidol challenge in mice.
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